Oulu Lyseo Upper Secondary School has two campuses that offer the Finnish national curriculum. These are the Oulun Lyseon lukio in the city centre and the August Sahlsten unit in Tyrnävä municipality. Oulun Lyseo also offers an IB Diploma Programme following the International Baccalaureate curriculum. 

Oulun Lyseon lukio main campus is in the centre of Oulu, in a building opened in 1831 and renovated in 2023.

The IB Diploma School is located in the same building as the Oulu International School (Kasarmintie 4) in the centre of Oulu, a five-minute walk from the main campus.

August Sahlsten -lukio is the remote campus of Oulun Lyseo in Tyrnävä. The school's teaching is a combination of local and distance learning in a cosy small school atmosphere in an old dairy building (Meijerikatu 4).